Aging results in the loss of gonadal hormones that leads to the dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis due to the loss of negative feedback of the gonadal hormones on the hypothalamus and pituitary, i.e. gonadal hormones decrease; pituitary and hypothalamic hormones increase. Our strategy to restore hormone balance, and to therefore slow or halt aging is to develop stem cell-based therapeutics intended to replace or regenerate gonadal cells that have been lost or are no longer functioning properly. We are advancing candidate cell therapies that are fit-for-purpose to the tissue into which they will be transplanted, and capable of producing the milieu of hormones needed to rebalance the HPG axis under the homeostatic influence of each individuals physiological requirements.
Each individual’s body requires continuously varying levels of numerous sex hormones that can only be regulated by the person’s own glandular tissues when functioning correctly. Pharmacological solutions, as indicated above, cannot rebalance all the hormones of the hypothalamic-pituitary-gonadal (HPG) axis. Our approach, repopulating the gonads with those cells that normally produce sex hormones, is expected to offer multiple advantages. These include: holistic hormonal rebalancing in accordance with the individual’s specific endocrine requirements; long-term, possibly permanent, restoration of circulating hormone levels, obviating the need for regular supplementation treatments; re-establishing the cyclical interactions of the HPG axis; utilization of the body’s own endocrine organs to drive the differentiation and maturation of stem cells into those cell types required to restore gonadal function.
This is truly personalized medicine.